Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Metabolic Glycoengineering of Synthetic "Membrane Receptors" via Supramolecular Host-Guest Recognition.

Bioconjugate chemistry·2026

Same author

Engineering a Glucose-Responsive Glucagon Prodrug Through Arginine-Phenylboronic Acid Pendant Modification.

Small science·2026

Same author

Programmable Host-Guest Recognition for Shape-Shifting Supramolecular Nanostructure States.

ACS nano·2025

Same author

Mechanistic Insights for Glucose-Driven Coacervation of a Supramolecular Peptide and Therapeutic Protein.

ACS applied materials & interfaces·2025

Same author

Diboronate-Modified Hyaluronic Acid for Glucose-Responsive Insulin Delivery.

Biomacromolecules·2025

Same author

Supramolecular Peptide Depots for Glucose-Responsive Glucagon Delivery.

Journal of biomedical materials research. Part A·2024

Search research articles

Related Experiment Video

Updated: Jun 13, 2026

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

Mechanoresponsive Hydrogels Emerging from Dynamic and Non-Covalent Interactions.

Rachel C Ollier¹, Matthew J Webber¹

¹Department of Chemical & Biomolecular Engineeripong, 105 McCourtney Hall, Notre Dame, IN, 46556, USA.

Advanced Materials (Deerfield Beach, Fla.)

|July 29, 2025

Summary

Dynamic hydrogels change properties with mechanical force, enabling self-healing and adaptable behaviors. This review explores how dynamic interactions drive these mechanoresponsive materials for new applications.

Keywords:

dynamic networks mechanical adaptability polymer science responsive materials rheology

More Related Videos

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

Area of Science:

Materials Science
Polymer Chemistry
Biomaterials Engineering

Background:

Mechanoresponsive hydrogels exhibit tunable properties upon mechanical stimulation.
Dynamic intermolecular interactions, rather than static covalent bonds, are key to these responses.
These interactions enable unique behaviors like self-healing and shear-thinning.

Purpose of the Study:

To review mechanoresponsive behaviors in dynamic hydrogels.
To examine the mechanisms, characterization, and applications of these materials.
To highlight the role of dynamic interactions in mechanoresponsive properties.

Main Methods:

Literature review of dynamic hydrogels and their mechanoresponsive behaviors.
Analysis of underlying mechanisms involving dynamic crosslinking motifs.
Discussion of characterization techniques and emerging applications.

Main Results:

Four distinct mechanoresponsive behaviors are identified: self-healing, shear-thinning, shear-thickening, and strain-stiffening.
Dynamic crosslinking is crucial for enabling reversible and tunable material responses.
These hydrogels offer potential in advanced applications requiring adaptive mechanical properties.

Conclusions:

Dynamic interactions are fundamental to the mechanoresponsive nature of advanced hydrogels.
Understanding these mechanisms facilitates the design of novel materials with tailored mechanical functions.
Mechanoresponsive hydrogels hold significant promise for future technological innovations.