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Updated: Sep 13, 2025

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Case 343.

Divij Agarwal1, Priyanka Naranje1, Neerja Gupta2

  • 1Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, Sri Aurobindo Marg, Ansari Nagar, New Delhi 110029, India.

Radiology
|July 29, 2025
PubMed
Summary
This summary is machine-generated.

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This case study highlights a rare presentation of gynecomastia in a adolescent male, complicated by thrombocytopenia and fractures. Early diagnosis and management are crucial for this rare condition.

Area of Science:

  • Endocrinology
  • Oncology
  • Radiology

Background:

  • A 17-year-old male presented with bilateral breast enlargement, multiple fractures, and hemoptysis.
  • Previous treatment with bisphosphonates provided only marginal symptom relief.

Purpose of the Study:

  • To investigate the underlying cause of gynecomastia, thrombocytopenia, and fractures in an adolescent male.

Main Methods:

  • Clinical examination, laboratory investigations (including platelet count and hormonal profile), chest radiography, diagnostic thoracentesis, contrast-enhanced CT, contrast-enhanced MRI, and echocardiography were performed.

Main Results:

  • Laboratory results revealed thrombocytopenia (platelet count of 100,000/µL) with a normal hormonal profile.
  • Imaging studies showed diffuse pericardial thickening and minimal hemorrhagic fluid upon thoracentesis.

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Conclusions:

  • The combination of gynecomastia, thrombocytopenia, and fractures in an adolescent male suggests a complex underlying condition requiring comprehensive diagnostic workup.
  • Further investigation is warranted to determine the etiology and guide appropriate management.