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Updated: Sep 13, 2025
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Author Spotlight: Analysis of Fluorescent-Stained Lipid Droplets with 3D Reconstruction for Hepatic Steatosis Assessment
Published on: June 2, 2023
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New insights into lipid droplet breakdown in alcohol-associated hepatic steatosis
Chen Zhang1, Wen-Xing Ding1,2
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA.
The Journal of Cell Biology
|July 29, 2025
Abstract:
The mechanisms by which alcohol increases lipid droplet accumulation are still unclear. In this issue, Sen et al. (https://doi.org/10.1083/jcb.202408205) identify a new pathway through which chronic alcohol exposure promotes hepatic steatosis via a UBXD8-p97/VCP-HSD17β13 axis, which regulates lipid droplet homeostasis.
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