Combined European and Japanese criteria to diagnose eosinophilic chronic rhinosinusitis

The recurrence of nasal polyps has frequently been observed with chronic rhinosinusitis with nasal polyps (CRSwNP), especially with asthma and N-ERD (NSAID-exacerbated respiratory disease). Patients with eosinophilic tissue infiltration are diagnosed as having eosinophilic chronic rhinosinusitis (ECRS), a unique CRSwNP subtype. Since the terminology of CRSwNP might include the patients with inflammatory polyps in addition to ECRS, the classification of CRSwNP by endotype is necessary to select the patients who require T2I-targeted biologic treatments. The concept of ECRS was established in 2001. However, a global consensus has not been reached regarding its definition due to the lack of standard histopathologic criteria and methodology for its classification.