Related Experiment Video
Updated: Sep 13, 2025
10:21
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
543
Transcriptomic Analysis Reveals C-C Motif Chemokine Receptor 1 as a Critical Pathogenic Hub Linking Sjögren's
Yanjun Lin1, Jingjing Su1, Shupin Tang2
1Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Fuzhou 350004, China.
Current Issues in Molecular Biology
|July 29, 2025
Summary
Sjögren's syndrome and periodontitis share a link, with C-C motif chemokine receptor 1 (CCR1) identified as a key gene. This research explores the immune mechanisms connecting these conditions.
Area of Science:
- Immunology
- Genetics
- Oral Medicine
Background:
- Sjögren's syndrome (SS) and periodontitis (PD) exhibit a bidirectional relationship.
- The molecular mechanisms underlying the co-occurrence of SS and PD are not fully understood.
- Identifying shared genetic factors is crucial for understanding disease pathogenesis.
Purpose of the Study:
- To investigate common genes and their connections between SS and PD.
- To identify a potential hub gene linking the two conditions.
- To explore the role of immune cell infiltration in the co-occurrence of SS and PD.
Main Methods:
- Differentially expressed genes (DEGs) analysis, gene set enrichment analysis (GSEA), and weighted gene co-expression network analysis (WGCNA).
- Least absolute shrinkage and selection operator (LASSO) regression to identify a unique shared gene.
- Receiver operating characteristic (ROC) curves for validation.
- CIBERSORT algorithm for immune cell infiltration analysis.
Main Results:
- Ninety-five common genes were identified through DEG analysis, enriched in immune-related pathways.
- Thirty-nine common genes were identified via WGCNA.
- C-C motif chemokine receptor 1 (CCR1) was identified as the unique shared hub gene by LASSO, showing overexpression and predictive value in ROC curves.
- Immune cell infiltration analysis highlighted its role in immune dysregulation.
Conclusions:
- CCR1 is a critical pathogenic hub gene linking Sjögren's syndrome and periodontitis.
- CCR1 may exert its influence through modulation of immune cell infiltration.
- Understanding the role of CCR1 and immune cells could lead to novel therapeutic strategies for both conditions.
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