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Phytochemicals in Breast Cancer Prevention and Therapy: Mechanisms, Efficacy, and Future Prospects

Neha Kodali1, Chikezie O Madu2, Yi Lu3

  • 1Department of Biology, University of Memphis, Memphis, TN 38152, USA.

Current Issues in Molecular Biology
|July 29, 2025
PubMed

Insights

Phytochemicals, plant compounds, show promise in combating breast cancer by influencing key cellular processes like apoptosis and cell cycle regulation. This review explores their mechanisms, dietary sources, and therapeutic potential.

Area of Science:

  • Oncology
  • Pharmacology
  • Nutritional Science

Background:

  • Breast cancer is a leading global cancer in women.
  • Phytochemicals are plant-derived compounds with potential anti-cancer properties.
  • Research is exploring phytochemicals for cancer prevention and treatment.

Purpose of the Study:

  • To review the mechanisms of phytochemicals in breast cancer.
  • To examine dietary sources and therapeutic integration of phytochemicals.
  • To discuss safety, toxicity, and future directions.

Main Methods:

  • Literature review of scientific studies on phytochemicals and breast cancer.
  • Analysis of cellular pathways modulated by phytochemicals.
  • Evaluation of existing research on efficacy and safety.

Main Results:

  • Phytochemicals modulate critical pathways including apoptosis, cell cycle, angiogenesis, and metastasis.
  • Various dietary sources rich in phytochemicals are identified.
  • Potential for phytochemicals in breast cancer therapy is highlighted.

Conclusions:

  • Phytochemicals offer a promising natural approach to breast cancer management.
  • Further research is needed to optimize their therapeutic use and understand safety profiles.
  • Dietary intake of phytochemicals may play a role in breast cancer prevention and support.
Keywords:
breast cancerphytochemicalspreventiontherapy

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