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The Aging Lung: Exploring Multimorbidity Patterns and Their Clinical Implications: A Narrative Review
Ali Albarrati1,2, Nichola S Gale1
1School of Healthcare Sciences, Cardiff University, University Hospital of Wales, Cardiff CF14 4XN, UK.
Current Issues in Molecular Biology
|July 29, 2025
Summary
Aging accelerates chronic lung disease and multiple conditions through inflammaging and cellular aging. Comprehensive care and novel therapies like senolytics can mitigate decline and improve patient outcomes.
Area of Science:
- Gerontology
- Pulmonology
- Internal Medicine
Background:
- Aging is a complex biological process involving cellular decline and reduced resilience, increasing chronic disease risk.
- Chronic lung diseases are prevalent in older adults and linked to systemic issues in cardiovascular, musculoskeletal, and neurological systems.
- Inflammaging and cellular aging are key mechanisms connecting aging, chronic conditions, and lung disease.
Purpose of the Study:
- To review biological mechanisms linking aging, multiple chronic conditions, and chronic lung disease.
- To explore shared pathological pathways like oxidative stress and mitochondrial dysfunction.
- To discuss the systemic impact of chronic conditions on aging individuals and advocate for integrated care.
Main Methods:
- Literature review focusing on aging, chronic lung disease, and comorbidities.
- Analysis of cellular and molecular mechanisms, including inflammaging and senescence.
- Examination of systemic effects and patient outcomes.
Main Results:
- Aging exacerbates chronic lung disease via inflammaging and cellular aging.
- Shared pathways include oxidative stress, mitochondrial dysfunction, and impaired repair.
- Multiple chronic conditions worsen frailty, physical capacity, cognition, and mortality risk.
Conclusions:
- A patient-centered approach integrating early detection, targeted therapies, and lifestyle interventions is crucial.
- Pharmacological treatments targeting inflammatory and senescent pathways show promise.
- Emerging therapeutics like senolytics offer new hope for managing age-related lung decline and comorbidities.
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