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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

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Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

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Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
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Local Anesthetics: Adverse Effects01:12

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While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
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Updated: Sep 13, 2025

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Serious and Progressive Neuropathy Presumably Post-Shingrix Vaccination.

Michael J Wons1, Avani Vaghela1, Amna Khalid1

  • 1Department of Biomedical Sciences, Rocky Vista University, Ivins, UT 84738, USA.

Reports (MDPI)
|July 29, 2025
PubMed
Summary
This summary is machine-generated.

A rare case of serious neuropathy developed after the herpes zoster subunit (HZ/su) vaccine (Shingrix). This report highlights the importance of documenting rare vaccine adverse events for better risk assessment.

Keywords:
Shingrixneuropathyvaccinevaricella

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Area of Science:

  • Neurology
  • Immunology
  • Vaccinology

Background:

  • The herpes zoster subunit (HZ/su) vaccine (Shingrix) is highly effective for preventing shingles.
  • Adverse events following immunization are closely monitored for vaccine safety.
  • Neuropathy is a recognized but rare potential side effect of vaccinations.

Observation:

  • A patient developed serious and progressive neuropathy one week after receiving the HZ/su vaccine.
  • Neuropathy symptoms persisted with mild residual effects at the time of discharge.
  • The patient's diagnosis and treatment for neuropathy were not fully confirmed.

Findings:

  • The incidence of neuropathy following HZ/su vaccination is exceedingly rare, estimated at three cases per million doses.
  • A black box warning exists for the HZ/su vaccine regarding neurological events.
  • This case underscores the need for continued surveillance of rare vaccine-associated adverse events.

Implications:

  • Reporting such cases is vital for understanding the full spectrum of vaccine risks.
  • Further research may elucidate the underlying mechanisms of vaccine-induced neuropathy.
  • Comprehensive data collection aids in refining vaccine safety profiles and public health recommendations.