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Serious and Progressive Neuropathy Presumably Post-Shingrix Vaccination
Michael J Wons1, Avani Vaghela1, Amna Khalid1
1Department of Biomedical Sciences, Rocky Vista University, Ivins, UT 84738, USA.
Reports (MDPI)
|July 29, 2025
Summary
A rare case of serious neuropathy developed after the herpes zoster subunit (HZ/su) vaccine (Shingrix). This report highlights the importance of documenting rare vaccine adverse events for better risk assessment.
Area of Science:
- Neurology
- Immunology
- Vaccinology
Background:
- The herpes zoster subunit (HZ/su) vaccine (Shingrix) is highly effective for preventing shingles.
- Adverse events following immunization are closely monitored for vaccine safety.
- Neuropathy is a recognized but rare potential side effect of vaccinations.
Observation:
- A patient developed serious and progressive neuropathy one week after receiving the HZ/su vaccine.
- Neuropathy symptoms persisted with mild residual effects at the time of discharge.
- The patient's diagnosis and treatment for neuropathy were not fully confirmed.
Findings:
- The incidence of neuropathy following HZ/su vaccination is exceedingly rare, estimated at three cases per million doses.
- A black box warning exists for the HZ/su vaccine regarding neurological events.
- This case underscores the need for continued surveillance of rare vaccine-associated adverse events.
Implications:
- Reporting such cases is vital for understanding the full spectrum of vaccine risks.
- Further research may elucidate the underlying mechanisms of vaccine-induced neuropathy.
- Comprehensive data collection aids in refining vaccine safety profiles and public health recommendations.
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