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Hyaluronan-Based Rapid-Gelling Hemostatic Powder to Bridge Dynamic Wound Sealing and Tissue Regeneration
Kai Wu1, Junhao Li1, Hanzhang Ran1
1National Engineering Research Center for Biomaterials, College of Biomedical Engineering, Sichuan University, Chengdu, Sichuan 610065, China.
Biomacromolecules
|July 29, 2025
Summary
A novel bioinspired hemostatic powder, GSHD, rapidly controls bleeding by forming a robust hydrogel. This advanced material also promotes tissue regeneration, addressing a key clinical need.
Area of Science:
- Biomaterials Engineering
- Regenerative Medicine
- Hemostasis
Background:
- Effective hemostatic materials that also promote tissue regeneration are crucial for clinical applications.
- Current hemostats often lack regenerative capabilities, limiting their utility beyond emergency bleeding control.
Purpose of the Study:
- To engineer a bioinspired hemostatic powder (GSHD) with rapid gelling and regenerative properties.
- To evaluate the hemostatic efficacy and tissue regenerative potential of GSHD in preclinical models.
Main Methods:
- GSHD was synthesized via molecular conjugation of thiolated gelatin and dopamine-modified hyaluronic acid.
- Hemostatic performance was assessed by measuring hydration, absorption, adhesion, and burst pressure.
- In vivo hemostasis and tissue regeneration were evaluated in rat models (liver, cardiac, femoral artery).
Main Results:
- GSHD rapidly formed a robust hydrogel (<5 s) with high blood absorption (569.2 ± 46.3%) and tissue adhesion (28.3 ± 3 kPa).
- Effective hemostasis (<30 s) was achieved in vivo with minimal blood loss.
- GSHD promoted M2 macrophage polarization, enhanced angiogenesis, and supported organized collagen deposition for tissue repair.
Conclusions:
- GSHD demonstrates superior hemostatic capabilities and significant regenerative potential.
- This bioinspired material offers a promising solution for bridging emergency hemostasis with functional tissue repair.
