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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

770
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
770

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The Relationship Between MRI-Measured Structure of the Visual Cortex and Visual Function in Patients With Glaucoma.

Akio Yamada1, Yasuko Tatewaki2, Kazuko Omodaka1

  • 1Department of Ophthalmology, Tohoku University Graduate School of Medicine.

Journal of Glaucoma
|July 29, 2025
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Summary

The peripheral visual field area in the brain's primary visual cortex is linked to glaucoma. Magnetic resonance imaging (MRI) can assess this brain region for glaucoma monitoring.

Keywords:
brainglaucomaoptical coherence tomographyprimary visual cortexvisual field

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Radiology

Background:

  • Glaucoma is known to cause atrophy in the primary visual cortex.
  • Understanding which specific areas of the visual cortex are most affected by glaucoma is crucial for diagnosis and monitoring.
  • Retinotopic mapping defines the relationship between the visual field and the primary visual cortex.

Purpose of the Study:

  • To investigate the relationship between ophthalmic parameters and structural changes in the primary visual cortex using magnetic resonance imaging (MRI).
  • To identify specific regions within the primary visual cortex that reflect glaucomatous changes.

Main Methods:

  • 12 healthy subjects and 23 glaucoma patients underwent 3D-T1-weighted MRI to measure gray matter density in the visual cortex.
  • Optical coherence tomography and visual field testing were performed.
  • Weighted count of retinal ganglion cells (wRGC) was calculated, and Spearman rank correlation was used to analyze relationships.

Main Results:

  • The overall primary visual cortex showed positive correlations with mean deviation (MD) and wRGC.
  • The inner area of the visual cortex, corresponding to the peripheral visual field, was significantly correlated with MD and wRGC.

Conclusions:

  • The peripheral visual field representation in the primary visual cortex is closely associated with key ophthalmologic parameters in glaucoma.
  • MRI evaluation of this specific brain region may offer clinical utility for glaucoma assessment and progression monitoring.