Hospital-cyclotrons production of high-purity ¹⁵⁵Tb via ¹⁵⁵Gd(p,n)

Terbium radionuclides are gaining prominence in theranostics, with ¹⁵⁵Tb emerging as promising SPECT imaging agent due to its γ emissions (87 keV, 32%; 105 keV, 25%) and favorable half-life (T_1/2=5.32 days), allowing extended biodistribution monitoring. However, efficient production via hospital cyclotrons is challenging, particularly in reducing ¹⁵⁶Tb contamination, which affects image quality and increases patient dose. This study investigates the ¹⁵⁵Gd(p,n)¹⁵⁵Tb reaction, highlighting the importance of ¹⁵⁵Gd target enrichment.