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Association of xerostomia and polypharmacy - A case-control study
1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS) University, Saveetha University, Chennai, India.
Community Dental Health
|July 29, 2025
Summary
Polypharmacy, the use of multiple medications, is significantly linked to xerostomia (dry mouth) in dental patients. Specific drug classes like antipsychotics and antidepressants also contribute to dry mouth risk.
Area of Science:
- Oral Medicine
- Pharmacology
Background:
- Xerostomia (dry mouth) impairs speech, swallowing, and oral hygiene.
- Understanding factors contributing to xerostomia is crucial for patient care.
Purpose of the Study:
- To investigate the association between polypharmacy and xerostomia in dental patients.
- To identify specific medication classes linked to xerostomia.
Main Methods:
- A case-control study involving 120 participants (60 with xerostomia, 60 without).
- Data collected from electronic records (Jan 2023-Jan 2024) including age, gender, and medication history.
- Multivariate regression analysis was employed to assess associations.
Main Results:
- Xerostomia prevalence was higher in females and specific age groups (31-40, 61-70).
- Polypharmacy showed a significant positive association with xerostomia (OR = 3.545).
- Antipsychotics, hypoglycemics, and antidepressants were common monotherapy drugs in xerostomia patients.
Conclusions:
- Polypharmacy is a significant risk factor for developing xerostomia.
- The number and type of medications prescribed are key contributors to xerostomia risk.
- Targeting medication regimens may help mitigate xerostomia in at-risk individuals.
Keywords:
antihypertensivesdiabetes mellitusgeriatricpolypharmacysalivary gland hypofunctionxerostomiaMore Related Videos
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