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RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic

Jialin Lu1, Ye Gao1, Qiuxin Li1

  • 1Department of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, 168 Changhai Road, Shanghai 200433, China.

Critical Reviews in Oncology/Hematology
|July 29, 2025
PubMed

Insights

N4-acetylcytidine (ac4C) is a crucial RNA modification impacting gastrointestinal cancer. Understanding ac4C

Area of Science:

  • Epigenetics and molecular oncology
  • RNA biology and cancer mechanisms

Background:

  • Gastrointestinal cancers are a major global health concern.
  • Epigenetic factors, including RNA modifications, play a key role in cancer development.
  • N4-acetylcytidine (ac4C) is an increasingly recognized RNA modification with significant biological functions.

Purpose of the Study:

  • To review the current knowledge on RNA ac4C modifications in gastrointestinal cancers.
  • To elucidate the functions, regulators, and mechanisms of ac4C in cancer progression and drug resistance.
  • To explore therapeutic strategies targeting ac4C modifications.

Main Methods:

  • Comprehensive literature review of studies on ac4C RNA modifications.
  • Analysis of recent advances in analytical chemistry and high-throughput sequencing.
  • Synthesis of evidence on ac4C's role in gastrointestinal cancer biology.

Main Results:

  • ac4C is a conserved RNA modification involved in critical biological functions.
  • Emerging evidence highlights ac4C's role in the malignant progression of gastrointestinal cancers.
  • ac4C influences gastrointestinal cancer development, progression, and drug resistance.

Conclusions:

  • RNA ac4C modifications are pivotal in gastrointestinal cancer.
  • Targeting ac4C presents a promising avenue for novel therapeutic strategies.
  • Further research into ac4C modulation could lead to more effective cancer treatments.
Keywords:
Cancer progressionGastrointestinal cancersN4-acetylcytidine (ac4C)RNA modificationsTherapeutic strategies

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