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Topical minoxidil for androgenetic alopecia: When blood pressure agents make you hairy

Émélie Braschi1, Alexander Kiciak2, Jennifer Young3

  • 1Hospitalist at the Élisabeth-Bruyère Hospital in Ottawa, Ont, and a physician adviser at the College of Family Physicians of Canada (CFPC).

Canadian Family Physician Medecin De Famille Canadien
|July 29, 2025
PubMed
Abstract

No abstract available in PubMed .

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Antihypertensive Drugs: Vasodilators01:23

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Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
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Hair growth begins with the production of keratinocytes by the basal cells of the hair bulb. As new cells are deposited at the hair bulb, the hair shaft is pushed through the follicle toward the surface. Keratinization is completed as the cells are pushed to the skin surface to form the shaft of hair that is externally visible. The external hair is completely dead and composed entirely of keratin. Hair can be cut or shaven without damaging the hair structure because the cut is superficial. Most...
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