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Updated: Sep 13, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Discovery of Structurally Diverse γ-Pyrone-Type Diterpenoids Produced by the Fungus Mariannaea sp. FKR-1011 from
Kazuki Tani1, Miyu Wakatsuki1, Masahiro Wada1
1Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
Abstract:
Seven γ-pyrone-type diterpenoids, including four new compounds (candelalides D-G (1-4)) and three known compounds (candelalides A-C (5-7)), were isolated from the solid culture material of the fungus Mariannaea sp. strain FKR-1011, obtained from Zamami Island, Okinawa, Japan. The chemical structures and relative configurations of 1-4 were determined by spectroscopic analysis such as FT-IR, NMR, and HR-ESI-MS. The absolute configurations of 1-4 were determined through extensive spectroscopic data analysis and TDDFT-ECD calculations. The isolated compounds were tested for biological activity, revealing antibacterial activity against methicillin-resistant Staphylococcus aureus in combination with β-lactam antibiotics and antimalarial activity against Plasmodium falciparum K1 and FCR3 strains.
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