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Related Experiment Video

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A Flexible Fluid Delivery System for Rodent Behavior Experiments.

Bruno F Cruz1,2, Paulo Carriço1, Luís Teixeira1

  • 1Champalimaud Research, Champalimaud Foundation, Lisbon 1400-038, Portugal.

Eneuro
|July 29, 2025
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Summary
This summary is machine-generated.

Researchers developed an open-source system for precise, automated delivery of small liquid volumes (<1μl) crucial for behavioral neuroscience experiments. This reproducible system enhances animal training and decision-making studies.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Instrumentation

Background:

  • Precise liquid delivery is essential for experimental behavioral neuroscience.
  • Automated reinforcement enables complex behavioral tasks and decision-making studies.
  • Existing systems may lack precision or open-source accessibility for small volumes.

Purpose of the Study:

  • Introduce a novel, open-source, stepper motor-based system for reproducible, small-volume liquid delivery (<1μl).
  • Provide a fully integrated solution controllable via software (Harp protocol) or direct I/O.
  • Offer comprehensive documentation including schematics and assembly instructions.

Main Methods:

  • Developed a stepper motor-driven liquid delivery system.
  • Integrated software control using the Harp protocol (Bonsai, Python).
  • Utilized computer vision for precise measurement of delivered volumes and validated with rodent psychophysics and electrophysiology.

Main Results:

  • Demonstrated reproducible delivery of sub-microliter liquid volumes.
  • System validated for accuracy and reliability in behavioral tasks.
  • Successful integration with electrophysiological recordings.

Conclusions:

  • The developed open-source system offers a precise, reproducible, and accessible solution for small-volume liquid delivery in neuroscience.
  • This technology facilitates advanced behavioral experiments and neuroscientific research.
  • The system's flexibility and comprehensive documentation support widespread adoption.