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Updated: Sep 13, 2025
Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
Published on: December 8, 2010
Transcutaneous Oxygen Tension and Bradykinin Concentration During Rheocarna Therapy: Case Series
Takaya Handa1,2, Yoshiki Tsuji3, Hidemasa Okamoto3
1Department of Nephrology and Dialysis, Medical Research Institute Kitano Hospital, PIIF Tazuke-Kofukai, Osaka, Japan.
Introduction:
Rheocarna therapy is believed to improve circulation via vasodilation; however, few reports have evaluated peripheral circulation during treatment.
Methods:
Bradykinin plasma concentration, blood pressure (BP), and transcutaneous oxygen pressure (TcPO2) were measured in two patients with chronic limb-threatening ischemia during Rheocarna therapy.
Results:
Case 1 (wound grade 1) exhibited stable, high TcPO2 and no ulcer progression after 6 months. Case 2 (wound grade 2) showed a bradykinin spike and a drop in BP and TcPO2 40 min after Rheocarna therapy initiation. However, TcPO2 subsequently exhibited a marked improvement. Case 2 progressed to wound grade 3 after 6 months.
Conclusion:
Although Case 2 exhibited a bradykinin rise and a drop in BP and TcPO2 after treatment initiation, TcPO2 recovered by the end of the therapy session; this is the first report to quantitatively demonstrate that Rheocarna was associated with peripheral circulation improvement. Accordingly, TcPO2 may be a useful prognostic indicator.
