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Isolation and Identification of Waterborne Antibiotic-Resistant Bacteria and Molecular Characterization of their Antibiotic Resistance Genes
Published on: March 3, 2023
The hospital sink drain microbiome as a melting pot for AMR transmission to nosocomial pathogens
Gregory E McCallum1, James P J Hall2
1Department of Evolution, Ecology and Behaviour, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. G.E.McCallum@liverpool.ac.uk.
Abstract:
The hospital sink drain microbiome can harbour opportunistic pathogens and antimicrobial resistance genes (ARGs). Aspects of this habitat, such as exposure to disinfectants, antibiotics, nutrients, and body fluids could exacerbate horizontal gene transfer of ARGs and clinically impactful pathogen resistance. Here, we explore features of the hospital sink drain that may favour ARG acquisition and transmission, highlight studies providing evidence of transfer, and consider strategies to mitigate these risks.
Insights
Hospital sink drains harbor pathogens and antimicrobial resistance genes (ARGs). Environmental factors may promote ARG spread, necessitating mitigation strategies to prevent resistance transmission.
Area of Science:
- Microbiology
- Environmental Science
- Public Health
Background:
- Hospital sink drains serve as reservoirs for opportunistic pathogens.
- These environments harbor antimicrobial resistance genes (ARGs), posing a significant public health risk.
- Factors like disinfectants, antibiotics, and nutrient availability may promote ARG proliferation and transfer.
Purpose of the Study:
- To investigate the hospital sink drain microbiome.
- To explore features that facilitate ARG acquisition and transmission.
- To identify strategies for mitigating risks associated with ARGs in hospital sink drains.
Main Methods:
- Review of existing literature on hospital sink drain microbiomes.
- Analysis of environmental factors influencing microbial communities and gene transfer.
- Identification of potential mitigation strategies.
Main Results:
- Hospital sink drains are complex microbial habitats.
- Evidence suggests that environmental conditions can enhance horizontal gene transfer of ARGs.
- Opportunistic pathogens and ARGs are prevalent in these settings.
Conclusions:
- Hospital sink drains represent a critical niche for the development and dissemination of antimicrobial resistance.
- Understanding the ecological dynamics within these drains is crucial for infection control.
- Targeted interventions are needed to reduce the spread of ARGs from this reservoir.
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