Recent Advancements in Metal-Organic Framework-Based Microfluidic Chips for Biomedical Applications

Area of Science:

• Biomedical Engineering
• Materials Science
• Nanotechnology

Background:

• Microfluidic technologies offer precise fluid control and high-throughput capabilities.
• Metal-organic frameworks (MOFs) provide large surface areas, tunable porosity, and catalytic properties.
• Integrating MOFs with microfluidics creates powerful lab-on-a-chip platforms.

Purpose of the Study:

• To review recent advancements in MOF-based microfluidic systems.
• To highlight innovations in materials, fabrication, and diagnostic applications.
• To discuss challenges and future trends in this interdisciplinary field.

Main Methods:

• Review of recent literature on MOF-microfluidic integration.
• Focus on material innovations, fabrication techniques, and diagnostic applications.
• Emphasis on MOF nanozymes for enhanced biochemical reactions.

Main Results:

• MOF-microfluidic systems demonstrate enhanced capabilities for biosensing, drug delivery, tissue engineering, and microbial detection.
• MOF nanozymes significantly improve multiplexed testing and pathogen identification.
• Progress has been made in addressing stability, biocompatibility, and scalability.

Conclusions:

• The synergy between MOFs and microfluidics enables sophisticated lab-on-a-chip devices.
• These integrated systems offer significant potential for next-generation biomedical diagnostics and therapeutics.
• Future directions include responsive MOFs, AI-driven design, and clinical translation.