Dietary Principles, Interventions and Oxidative Stress in Psoriasis Management: Current and Future Perspectives

Area of Science:

• Dermatology
• Immunology
• Nutritional Science

Background:

• Psoriasis is a chronic inflammatory autoimmune disease impacting quality of life.
• Pathophysiology involves oxidative stress and an imbalance between antioxidant and pro-oxidant factors.
• Standard treatments can be challenging due to multifactorial causes.

Purpose of the Study:

• To explore the impact of dietary modifications and supplementation on psoriasis management.
• To evaluate the effectiveness of specific diets and vitamin D in improving psoriasis outcomes.
• To understand the role of oxidative stress and gut microbiome in psoriasis.

Main Methods:

• Review of studies examining dietary interventions and their effect on Psoriasis Area and Severity Index (PASI) scores.
• Analysis of the benefits of hypocaloric, Mediterranean, and ketogenic diets.
• Assessment of topical and oral vitamin D supplementation in psoriasis and psoriatic arthritis.

Main Results:

• Hypocaloric diets rich in antioxidants, emphasizing vegetables and reduced animal protein, significantly improve PASI scores.
• The Mediterranean diet shows benefits due to omega-3 fatty acids and gut microbiome modulation.
• Topical vitamin D and oral supplementation positively impact skin manifestations, psoriatic arthritis, and comorbidities.

Conclusions:

• Dietary choices are crucial for managing psoriasis and improving patient quality of life.
• Specific diets and vitamin D supplementation offer effective therapeutic strategies.
• Addressing oxidative stress and gut health is key in psoriasis management.