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Microbiota-A Rescuing Modulator in Children Struggling with Functional Constipation.
Nicoleta Ana Tomșa1, Lorena Elena Meliț2, Teodora Popescu1
1Doctoral School of Medicine and Pharmacy, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street, No. 38, 540136 Targu Mures, Romania.
Microorganisms
|July 30, 2025
Summary
Functional constipation in children is linked to gut microbiota changes. Probiotics show promise in improving symptoms by restoring beneficial bacteria and reducing inflammation, though more research is needed for standard use.
Area of Science:
- Pediatric Gastroenterology
- Microbiology
- Immunology
Background:
- Functional constipation (FC) affects 30% of children, with 95% of cases being functional.
- FC involves alterations in gut peristalsis, influenced by the immune system, nervous system, bile acid metabolism, and gut microbiota.
Purpose of the Study:
- To review the role of gut microbiota in pediatric constipation.
- To assess the efficacy of probiotics in managing constipation in children.
Main Methods:
- Literature review of studies on gut microbiota and probiotics in pediatric functional constipation.
- Analysis of microbiota composition changes in chronic FC.
- Evaluation of probiotic mechanisms of action.
Main Results:
- Altered gut microbiota in chronic FC shows increased Bacteroidetes, Enterobacteriaceae, and Firmicutes, with decreased Prevotella, Bifidobacteria, Faecalibacterium prausnitzii, and Clostridium leptum.
- Probiotics like Bifidobacterium breve, Bifidobacterium longum, and Bifidobacterium animalis subsp. lactis XLTG11 may increase defecation frequency and reduce fecal incontinence and abdominal pain.
- Lactobacilli enhance gut motility and stool moisture through organic acid production.
Conclusions:
- Gut microbiota alterations are evident in pediatric functional constipation.
- Specific probiotic strains demonstrate potential benefits for constipation symptoms.
- Study heterogeneity currently limits the standardization of probiotics in pediatric constipation management.
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