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The Role of Microbial Exopolysaccharides in Preventing and Treating Cardiovascular Diseases

Enrique A Sanhueza-Carrera1,2, Cassiopeia Cantero-Ramírez1, Angel D Montijo-Valdés1

  • 1Laboratorio de Biomoléculas y Salud Infantil, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.

Microorganisms
|July 30, 2025
PubMed

Insights

Exopolysaccharides (EPSs) show promise as natural compounds for managing cardiovascular diseases (CVDs). These bioactive agents offer cardioprotective effects, acting as antioxidants and regulating blood pressure and cholesterol.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Biotechnology

Background:

  • Cardiovascular diseases (CVDs) are a leading global health crisis, causing significant mortality and disability.
  • Current pharmacological treatments for CVDs have limitations and side effects, necessitating alternative therapies.

Purpose of the Study:

  • To review the properties of exopolysaccharides (EPSs) as bioactive agents for cardiovascular health.
  • To highlight the mechanisms of EPSs in cardioprotection, including antioxidant, antihypertensive, and cholesterol-regulating effects.

Main Methods:

  • Literature review of studies on exopolysaccharides and cardiovascular diseases.
  • Analysis of cellular signaling pathways involved in EPSs' cardioprotective actions.

Main Results:

  • EPSs exhibit antioxidant properties, mitigating oxidative stress in cardiovascular conditions.
  • EPSs demonstrate antihypertensive effects and contribute to cholesterol regulation.
  • EPSs promote regenerative effects on vascular epithelia, supporting vascular health.

Conclusions:

  • Exopolysaccharides are promising biomolecules for the prevention and management of cardiovascular diseases.
  • EPSs offer a natural, potentially safer alternative or complementary therapy for CVDs.

Keywords:
cardiovascular diseasesexopolysaccharidespostbioticsprebioticsprobiotics

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