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Resveratrol Alleviates Inflammatory Response Through P2X7/NLRP3 Signaling Pathway: In Silico and In Vitro Evidence

Bianca Fagan Bissacotti1, Marcylene Vieira da Silveira1, Charles Elias Assmann1

  • 1Graduate Program in Biological Sciences: Toxicological Biochemistry, Department of Biochemistry and Molecular Biology, Federal University of Santa Maria (UFSM), Santa Maria 97105-900, RS, Brazil.

Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
PubMed
Summary

Resveratrol demonstrates anti-neuroinflammatory effects by modulating NLRP3 inflammasome and P2X7 receptor pathways in microglia. This suggests its potential as a therapeutic agent for brain diseases linked to chronic inflammation.

Keywords:
BV-2 cellsbrain inflammationimmunomodulationpolyphenolpurinergic receptors

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