Recent Advances in the Application of Silver Nanoparticles for Enhancing Phototherapy Outcomes

The therapeutic use of silver nanoparticles (AgNPs) has been increasing, especially in phototherapy strategies. The plasmonic properties of AgNPs have contributed to their excellent results as phototherapeutic agents, namely for photodynamic therapy (PDT), photothermal therapy (PTT), and photodynamic inactivation of microorganisms. Moreover, the capacity of these nanostructures to release silver ions (Ag⁺) and enhance the production of reactive oxygen species (ROS) has been explored in combination with light to treat several diseases. Moreover, synthesis, functionalization, and conjugation strategies with targeting agents have been widely studied to optimize selectivity and maximize the therapeutic efficacy of these nanoplatforms. In this work, we reviewed the recent advancements (2019-2024) in the use of AgNPs for phototherapy applications, with an emphasis on evaluating therapeutic efficacy and specific targeting. According to the literature, in oncology, AgNPs have been predominately employed in PTT-based strategies, demonstrating significant tumor cell death and preservation of healthy tissues, in both in vitro and in vivo studies. Concurrently, AgNP-mediated PDT has emerged as a promising approach for the eradication of bacteria and fungi, particularly those commonly associated with antibiotic resistance. The compiled data indicate that AgNPs represent an innovative and effective therapeutic alternative, with a strong potential for clinical translation, in both cancer treatment and the management of hard-to-treat infections.