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Scale-Agnostic Models Based on Dimensionless Quality by Design as Pharmaceutical Development Accelerator

Miquel Romero-Obon1, Virginia Sancho-Ochoa1, Khadija Rouaz-El-Hajoui1,2

  • 1Department of Pharmacy and Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Av. Joan XXIII, 27-31, 08028 Barcelona, Spain.

Pharmaceuticals (Basel, Switzerland)
|July 30, 2025
PubMed
Summary

Quality by Design (QbD) and the Pi-Buckingham theorem enhance pharmaceutical product development. This synergy improves process optimization and manufacturing outcomes by controlling critical quality attributes.

Keywords:
Pi–BuckinghamQuality by Designdesign of experimentsdesign spacedimensional analysispharmaceutical process development

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