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Updated: Sep 13, 2025

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
Published on: November 19, 2012
Adaptive Curved Slicing for En Face Imaging in Optical Coherence Tomography
Mingxin Li1, Phatham Loahavilai1, Yueyang Liu1
1State Key Laboratory of Precision Measurement Technology and Instrument, Department of Precision Instrument, Tsinghua University, Beijing 100084, China.
None:
Optical coherence tomography (OCT) employs light to acquire high-resolution 3D images and is widely applied in fields such as ophthalmology and forensic science. A popular technique for visualizing the top view (en face) is to slice it with flat horizontal plane or apply statistical functions along the depth axis. However, when the target appears as a thin layer, strong reflections from other layers can interfere with the target, rendering the flat-plane approach ineffective. We apply Otsu-based thresholding to extract the object's foreground, then use least squares (with Tikhonov regularization) to fit a polynomial curve that describes the sample's structural morphology. The surface is then used to obtain the latent fingerprint image and its residues at different depths from a translucent tape, which cannot be analyzed using conventional en face OCT due to strong reflection from the diffusive surface, achieving FSIM of 0.7020 compared to traditional en face of 0.6445. The method is also compatible with other signal processing techniques, as demonstrated by a thermal-printed label ink thickness measurement confirmed by a microscopic image. Our approach empowers OCT to observe targets embedded in samples with arbitrary postures and morphology, and can be easily adapted to various optical imaging technologies.
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