Functional Nanomaterials for Advanced Bioelectrode Interfaces: Recent Advances in Disease Detection and Metabolic
Junlong Ma1,2,3,4,5, Siyi Yang1,2,3,4,5, Zhihao Yang1,2,3,4,5
1The Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.
Sensors (Basel, Switzerland)
|July 30, 2025
Summary
Functional nanomaterials significantly improve bioelectrode performance for biosensors, enhancing disease detection and metabolic monitoring. This review highlights advancements and challenges in nanomaterial-based bioelectrode interfaces for medical applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Bioelectrodes are crucial interfaces between biological systems and electronic devices, directly impacting biosensor performance.
- Advancements in functional nanomaterials have significantly improved bioelectrode capabilities for various applications.
Purpose of the Study:
- To systematically review recent progress in nanomaterial-enabled bioelectrode interface design.
- To analyze performance enhancements in signal acquisition and multimodal sensing.
- To discuss challenges and future perspectives for translational applications.
Main Methods:
- Review of recent literature on nanomaterial-enabled bioelectrode interfaces.
- Analysis of material selection, structural engineering, and interface modification strategies.
- Examination of advancements in electrophysiological/electrochemical signal acquisition and multimodal sensing.
Main Results:
- Nanomaterials enhance bioelectrode sensitivity, selectivity, and reliability for disease detection and metabolic monitoring.
- Cutting-edge developments include dynamic metabolic monitoring for chronic diseases and flexible interfaces for early diagnosis.
- Progress has been made in strategic material selection, structural engineering, and interface modification.
Conclusions:
- Nanomaterial-enabled bioelectrodes show great promise for wearable medical devices and personalized health management.
- Addressing challenges in biocompatibility and long-term stability is crucial for translational applications.
- This review provides a framework for researchers in the interdisciplinary field of bioelectrode development.
