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Published on: October 11, 2018
Fatal Paraclostridium sordellii Infection: Post-Mortem Assessment and Review of the Literature
Martina Focardi1, Simone Faccioli1, Beatrice Defraia1
1Forensic Medical Sciences, Department of Health Science, University of Florence, 50100 Florence, Italy.
Abstract:
Clostridium sordellii, which has recently been reclassified as Paeniclostridium sordellii and subsequently as Paraclostridium sordellii, is a rare human pathogen linked to infections of high morbidity and mortality, often presenting as fulminant toxic shock syndrome. Although most documented cases involve individuals with pre-existing health issues, such as immunosuppression and cancer, or those who have undergone specific gynecological procedures, there are few instances reported in otherwise healthy individuals. In this report, we present a case of fatality associated with P. sordellii infection in a young individual with a history of drug abuse, following post-mortem examinations. Additionally, we provide an updated review of the latest literature on this topic.
Insights
Paraclostridium sordellii (P. sordellii) is a rare pathogen causing severe toxic shock syndrome. This report details a fatal P. sordellii infection in a young drug user, highlighting its potential in seemingly healthy individuals.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Toxicology
Background:
- Paraclostridium sordellii (formerly Clostridium sordellii) is a rare bacterium causing severe infections.
- Infections often manifest as toxic shock syndrome with high mortality.
- Cases typically involve immunocompromised individuals or those with specific gynecological histories.
Purpose of the Study:
- To report a fatal case of P. sordellii infection in a young individual with a history of drug abuse.
- To review the current literature on P. sordellii infections.
- To emphasize the potential for P. sordellii to cause severe disease in diverse populations.
Main Methods:
- Case report presentation.
- Post-mortem examination.
- Literature review of P. sordellii infections.
Main Results:
- A young individual with a history of drug abuse died from P. sordellii infection.
- The infection presented as a severe, fulminant illness.
- Literature review confirms the association of P. sordellii with high morbidity and mortality.
Conclusions:
- Paraclostridium sordellii can cause fatal infections even in individuals without typical predisposing factors.
- Drug abuse may represent an underrecognized risk factor for P. sordellii infection.
- Continued vigilance and research are necessary for understanding and managing P. sordellii infections.
