Endogenous cholecystokinin and intestinal satiety

Area of Science:

• Gastroenterology
• Neuroscience
• Physiology

Background:

• Endogenous cholecystokinin (CCK) is a gut hormone implicated in regulating appetite and satiety.
• Understanding the precise role of CCK in intestinal satiety is crucial for comprehending feeding behavior regulation.

Purpose of the Study:

• To investigate the role of endogenous CCK in mediating intestinal satiety.
• To quantify the contribution of CCK to the suppression of feeding induced by intraduodenal nutrient infusion.

Main Methods:

• Rats with chronic gastric fistulas and indwelling duodenal catheters were used for sham feeding experiments.
• Intraduodenal infusions of liquid diet were administered to assess feeding suppression.
• Proglumide, a specific CCK antagonist, was used to evaluate CCK's contribution.

Main Results:

• Intraduodenal liquid diet infusions significantly suppressed sham feeding.
• Proglumide partially reversed the feeding suppression from an 11-ml infusion but not a 5-ml infusion.
• Proglumide abolished feeding suppression by exogenous CCK but did not affect basal feeding.

Conclusions:

• Endogenous CCK contributes to intestinal satiety under specific conditions, but its role is limited.
• Factors other than CCK play a more significant role in mediating overall intestinal satiety.
• CCK's involvement in satiety is dose-dependent and influenced by nutrient load.