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Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Related Experiment Video

Updated: Sep 13, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Exploring Individual Factors Affecting Endothelial Function Response Variability in Aging: Implications for Precision

Emily K Woolf1, Leanne M Redman1

  • 1Reproductive Endocrinology and Women's Health Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.

Nutrients
|July 30, 2025
PubMed
Summary
This summary is machine-generated.

Dietary interventions can improve vascular endothelial function in older adults, but responses vary significantly. Future research should identify factors causing this variability to enable personalized nutrition for cardiovascular disease prevention.

Keywords:
endothelial functionflow-mediated dilationhealthy aginginterindividual variabilitynutrition and agingprecision nutrition

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Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Nutritional Science

Background:

  • Aging is a primary non-modifiable risk factor for cardiovascular disease (CVD), significantly impacting vascular endothelial function.
  • Dietary interventions, like plant-based diets or the Mediterranean Diet, can improve endothelial function in older adults, measured by flow-mediated dilation (FMD).
  • Individual variability in FMD response to dietary changes poses a challenge for population-level CVD prevention strategies.

Purpose of the Study:

  • To review nutritional interventions that enhance endothelial function in aging.
  • To identify factors contributing to individual variability in response to these interventions.
  • To propose future research directions for precision nutrition in aging populations.

Main Methods:

  • This narrative review synthesizes existing research on dietary interventions and endothelial function in aging.
  • It examines studies assessing flow-mediated dilation (FMD) as a measure of endothelial function.
  • The review discusses potential sources of inter-individual variability in treatment response.

Main Results:

  • Nutritional strategies can positively influence endothelial function in older adults.
  • Significant variability exists in how individuals respond to dietary interventions aimed at improving vascular health.
  • Understanding this variability is crucial for developing effective, personalized approaches.

Conclusions:

  • Personalized nutrition strategies are needed to optimize cardiovascular disease prevention in aging populations.
  • Further research into the drivers of individual response variability is essential.
  • Tailoring dietary recommendations will enhance clinical relevance and advance precision nutrition for older adults.