Related Experiment Video
Updated: Sep 13, 2025

Fabricating Reactive Surfaces with Brush-like and Crosslinked Films of Azlactone-Functionalized Block Co-Polymers
Published on: June 30, 2018
Tertiary Amine Oxide-Containing Zwitterionic Polymers: From Material Design to Biomedical Applications
Jian Shen1, Tao Sun2,3,4, Yunke Bi5
1College of Chemistry, Chemical and Environmental Engineering, Weifang University, Weifang 261061, China.
Abstract:
Tertiary amine oxide (TAO)-containing zwitterionic polymers are a class of zwitterionic materials formed by the oxidation of tertiary amine groups. In recent years, polymers such as poly(2-(N-oxide-N,N-diethylamino)ethyl methacrylate) (OPDEA) have gained significant attention due to their unique antifouling properties, dynamic cell membrane affinity, and responsiveness to microenvironments. These characteristics have made them promising candidates in drug delivery, antibiofouling, and precision therapy. Compared to traditional polyethylene glycol (PEG), these polymers not only exhibit long-circulation properties but can also overcome biological barriers through active transport mechanisms, making them a research hotspot in the field of next-generation biomaterials. This review comprehensively summarizes the recent advancements in this field, covering aspects such as the synthesis, properties, applications, and mechanisms of TAO-containing zwitterionic polymers.
Related Concept Videos
Anionic Chain-Growth Polymerization: Overview
Nomenclature of Secondary and Tertiary Amines
Ion Exchange
Ziegler–Natta Chain-Growth Polymerization: Overview

