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Innovative Controlled-Release Systems for Fucoxanthin: Research Progress and Applications.

Shiyan Wang1, Mengran Guo1, Zhaohui Jin1

  • 1Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.

Pharmaceutics
|July 30, 2025
PubMed
Summary

Marine carotenoid fucoxanthin shows promise but faces bioavailability challenges. Controlled-release nanotechnologies, including bioinspired systems, are enhancing its pharmaceutical and nutraceutical applications by improving delivery and efficacy.

Keywords:
bioavailabilitycontrolled-release systemextracellular vesiclesfucoxanthinpoor aqueous solubility

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Area of Science:

  • Marine biotechnology
  • Carotenoid chemistry
  • Drug delivery systems

Background:

  • Fucoxanthin, a marine carotenoid from algae, has potential pharmaceutical and nutraceutical uses.
  • Its unsaturated structure causes instability, poor solubility, and low bioavailability, limiting applications.
  • Controlled-release nanotechnologies are being explored to overcome these limitations.

Purpose of the Study:

  • To review fucoxanthin's bioactivities and recent advancements in controlled-release systems.
  • To highlight nanotechnologies addressing fucoxanthin's formulation challenges.
  • To discuss emerging bioinspired delivery systems for enhanced fucoxanthin applications.

Main Methods:

  • Systematic review of scientific literature on fucoxanthin and controlled-release systems.
  • Analysis of various formulations: emulsions, nanoparticles, nanofibers, nanostructured lipid carriers.
  • Evaluation of bioinspired systems like extracellular vesicles and cell-membrane-derived systems.

Main Results:

  • Controlled-release systems using natural/synthetic materials improve fucoxanthin formulations.
  • Bioinspired systems offer superior encapsulation, immunocompatibility, and barrier penetration.
  • Delivery systems enhance biosafety, bioavailability, bioactivity preservation, and therapeutic performance.

Conclusions:

  • Advanced controlled-release and bioinspired systems are crucial for overcoming fucoxanthin's limitations.
  • These innovations unlock fucoxanthin's potential in drug development and dietary supplements.
  • Further research in engineered delivery platforms will optimize fucoxanthin's therapeutic value.