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Development of an Antimicrobial Coating Film for Denture Lining Materials
Kumiko Yoshihara1,2, Takeru Kameyama3, Noriyuki Nagaoka4
1National Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, Takamatsu 761-0395, Japan.
Pharmaceutics
|July 30, 2025
Summary
New denture coatings containing cetylpyridinium chloride-loaded montmorillonite (CPC-Mont) effectively prevent Candida albicans. These antimicrobial films offer temperature-responsive, reversible drug release for enhanced denture hygiene.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Oral Microbiology
Background:
- Denture hygiene is crucial for preventing oral candidiasis, often caused by Candida albicans.
- Cetylpyridinium chloride (CPC)-loaded montmorillonite (CPC-Mont) shows promise as an antimicrobial agent for oral applications.
- Developing effective antimicrobial coatings for dentures is essential for patient health.
Purpose of the Study:
- To develop and characterize CPC-Mont-containing coating films for dentures.
- To evaluate the physicochemical properties and antifungal efficacy of these novel coatings.
- To investigate the temperature-dependent release and recharging of CPC from the montmorillonite matrix.
Main Methods:
- Cetylpyridinium chloride (CPC) was intercalated into montmorillonite (CPC-Mont).
- CPC-Mont was incorporated into films using nonionic, cationic, and anionic emulsions.
- Physicochemical properties, CPC loading/release/recharging, and antimicrobial activity against Candida albicans were assessed.
Main Results:
- X-ray diffraction confirmed montmorillonite interlayer expansion upon CPC loading.
- CPC-Mont exhibited temperature-dependent, reversible release and recharging kinetics (activation energies: 38 kJ/mol release, 26 kJ/mol recharge).
- Nonionic emulsions yielded uniform films with sustained antimicrobial activity against Candida albicans.
Conclusions:
- CPC-Mont can be successfully integrated into nonionic emulsion-based films for denture coatings.
- These films demonstrate temperature-responsive, reversible CPC release, maintaining antifungal efficacy.
- CPC-Mont-containing films represent a promising strategy for preventing denture-related candidiasis.
