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Nanoradiopharmaceuticals: Design Principles, Radiolabeling Strategies, and Biomedicine Applications
Andrés Núñez-Salinas1, Cristian Parra-Garretón1, Daniel Acuña2
1Universidad Andres Bello, Escuela de Química y Farmacia, Facultad de Medicina. 8370016. Santiago. Chile.
Pharmaceutics
|July 30, 2025
Summary
Nanoradiopharmaceuticals combine nanotechnology and nuclear medicine for advanced cancer imaging and therapy. These nanocarriers offer improved targeting and stability, paving the way for personalized oncology treatments.
Area of Science:
- Nuclear Medicine
- Nanotechnology
- Oncology
Background:
- Nanoradiopharmaceuticals integrate nanotechnology with nuclear medicine.
- Nanomaterials enhance targeting and stability of radiopharmaceuticals.
- Limitations in current radiopharmaceuticals necessitate advanced solutions.
Purpose of the Study:
- Provide a comprehensive overview of nanoradiopharmaceuticals.
- Focus on their role in precision oncology.
- Examine design principles, radiolabeling, and applications.
Main Methods:
- Review of fundamental design principles and radiolabeling techniques.
- Assessment of diverse nanocarriers (liposomes, micelles, nanoparticles, etc.).
- Evaluation of preclinical and clinical research outcomes.
Main Results:
- Nanoradiopharmaceuticals show promise in SPECT, PET imaging, and radionuclide therapies.
- Theranostic nanoplatforms enable integrated diagnostics and therapeutics.
- Various nanocarriers demonstrate potential in preclinical and clinical studies.
Conclusions:
- Nanoradiopharmaceuticals are a promising frontier in personalized medicine, especially oncology.
- Integrated nanosystems facilitate individualized and adaptive cancer treatment.
- Further innovation in formulation, radiochemistry, and regulation is needed for clinical adoption.
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