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Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
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Functional Role of Resveratrol in Inducing Apoptosis in Breast Cancer Subtypes via Inhibition of Intracellular Fatty

Ping Li1,2, Yan Liang3, Xiaofeng Ma1

  • 1University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China.

Molecules (Basel, Switzerland)
|July 30, 2025
PubMed

Insights

Resveratrol inhibits fatty acid synthase (FASN) in breast cancer cells, reducing fatty acid levels and promoting cancer cell death. This suggests resveratrol is a potential therapeutic agent for breast cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Fatty acid synthase (FASN) is overexpressed in human breast cancer, presenting a therapeutic target.
  • Resveratrol demonstrates in vitro inhibition of FASN activity via reversible and irreversible mechanisms.

Purpose of the Study:

  • To investigate resveratrol's effect on FASN activity, expression, and breast cancer cell viability.
  • To explore the role of FASN inhibition in resveratrol-induced apoptosis and signaling pathway modulation.

Main Methods:

  • Treatment of breast cancer cell lines (SK-BR-3, MCF-7, MDA-MB-231) with resveratrol.
  • Fatty acid synthase (FASN) knockdown using small interfering RNA (siRNA).
  • Assessment of cell viability, apoptosis markers (PARP cleavage, Bcl-2 family proteins), and signaling pathways (FAK, AKT, ERK1/2).

Main Results:

  • Resveratrol inhibited FASN activity and downregulated its expression, reducing intracellular fatty acids across breast cancer subtypes.
  • FASN knockdown potentiated resveratrol-induced cytotoxicity and apoptosis.
  • Resveratrol suppressed cell viability, induced apoptosis, and inhibited FAK, AKT, and ERK1/2 signaling pathways.

Conclusions:

  • Resveratrol effectively inhibits FASN in various breast cancer cells, leading to reduced proliferation and induced apoptosis.
  • Combined FASN inhibition and resveratrol treatment enhance anti-cancer effects.
  • Resveratrol shows promise as an anti-cancer therapeutic by targeting FASN and associated signaling pathways in breast cancer.
Keywords:
breast cancer cellscell apoptosisfatty acid synthaseinhibitorresveratrol

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