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New 3D Spiral Microfluidic Platform Tested for Fe3O4@SA Nanoparticle Synthesis
Elena-Theodora Moldoveanu1, Adelina-Gabriela Niculescu1,2, Dana-Ionela Tudorache Trifa1
1Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology POLITEHNICA Bucharest, 011061 Bucharest, Romania.
Molecules (Basel, Switzerland)
|July 30, 2025
Summary
This study introduces a novel 3D spiral microfluidic platform for synthesizing and functionalizing magnetite nanoparticles. The platform offers a scalable, reproducible, and eco-friendly method for producing these nanomaterials for various applications.
Area of Science:
- Materials Science
- Nanotechnology
- Microfluidics
Background:
- Growing demand for reproducible, scalable, and green nanomaterial synthesis.
- Microfluidic technologies are gaining traction for advanced material production.
Purpose of the Study:
- To develop and test a novel 3D spiral microfluidic platform.
- To achieve simultaneous synthesis and surface functionalization of magnetite nanoparticles with salicylic acid.
Main Methods:
- Fabrication of a 3D spiral microfluidic chip using polymethylmethacrylate (PMMA).
- Continuous synthesis and functionalization of magnetite (Fe3O4) nanoparticles with salicylic acid (SA) on-chip.
- Physicochemical characterization and in vitro cytotoxicity assays.
Main Results:
- Successful synthesis of Fe3O4@SA nanoparticles with desired crystallinity, morphology, and size distribution.
- Demonstrated excellent colloidal stability and successful surface functionalization.
- Identified a safe in vitro dose range (<610 µg/mL) using lung fibroblast and keratinocyte cell lines.
Conclusions:
- The 3D microfluidic platform enables efficient, simultaneous synthesis and functionalization of Fe3O4@SA nanoparticles.
- The synthesized nanoparticles exhibit favorable physicochemical properties and biocompatibility.
- This platform is a promising tool for scalable nanomaterial production in biomedical and environmental fields.
