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Current Trends of Human Adenovirus Types Among Hospitalized Children-A Systematic Review
Janina Soler Wenglein1,2,3, Luca Scarsella2,4, Christine Kotlewski1
1Department of Pediatrics, Protestant Hospital of the Bethel Foundation, Medical School and University Medical Center East Westphalia-Lippe, Bielefeld University, 33617 Bielefeld, Germany.
Viruses
|July 30, 2025
Summary
Human adenoviruses (HAdVs) are common pathogens in children, causing various illnesses. This review synthesizes global data on prevalent HAdV types and their associated pediatric infections, emphasizing respiratory and neurological diseases.
Area of Science:
- Virology
- Pediatrics
- Infectious Diseases
Background:
- Human adenoviruses (HAdVs) are significant pathogens, particularly in pediatric and immunocompromised populations, presenting a wide spectrum of illnesses.
- Specific HAdV types, including B3, E4, B7, B14, B21, G55, and B66, are linked to severe lower respiratory tract infections, leading to increased hospitalization and mortality.
- Understanding the prevalence and clinical impact of diverse HAdV types in children is crucial for public health.
Approach:
- A systematic literature search was conducted across MEDLINE, Scopus, and Web of Science.
- 1167 titles and abstracts were screened, with 105 full-text articles assessed for eligibility following PRISMA and JBI guidelines.
- A systematic and narrative approach was used to synthesize data on 16 currently circulating HAdV types in pediatric populations.
Key Points:
- HAdV-B3 and HAdV-B7 are frequently associated with severe respiratory tract infections in children.
- HAdV-F40 and HAdV-F41 are primary causes of acute gastroenteritis in pediatric patients.
- HAdV-C2 plays a critical role in neurological infections, necessitating focused attention.
Conclusions:
- This comprehensive analysis underscores the global distribution and varied clinical manifestations of HAdV types in children.
- Continued surveillance of HAdVs epidemiology is essential for informing public health strategies and developing preventive measures.
- Particular attention should be given to vulnerable pediatric populations due to the significant implications of HAdV infections.
