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mRNA Vaccine Development in the Fight Against Zoonotic Viral Diseases
Brandon E K Tan1, Seng Kong Tham1, Chit Laa Poh1,2
1ALPS Global Holding Berhad, The Icon, East Wing Tower Level 18-01 & Level 18-02, No.1 Jalan 1/68F, Off Jalan Tun Razak, Kuala Lumpur 50400, Malaysia.
Viruses
|July 30, 2025
Summary
Messenger RNA (mRNA) vaccines offer a promising solution for combating zoonotic diseases, which spread from animals to humans. This technology enables rapid development to address emerging viral threats.
Area of Science:
- Veterinary Medicine
- Public Health
- Immunology
Background:
- Zoonotic diseases pose a significant global health and economic burden, transmitted between animals and humans.
- Drivers like climate change, urbanization, and travel accelerate the emergence and re-emergence of these diseases.
- The need for rapid vaccine development against novel zoonotic viruses is critical.
Purpose of the Study:
- To review recent advances in mRNA vaccine development for emerging and re-emerging zoonotic viral diseases.
- To explore the challenges and future directions in this field.
- To highlight the potential of mRNA platforms in combating zoonotic threats.
Main Methods:
- Review of recent scientific literature on mRNA vaccine technology.
- Analysis of clinical trial data for mRNA vaccines targeting zoonotic viruses.
- Exploration of factors influencing zoonotic disease emergence.
Main Results:
- mRNA vaccines have shown promising immunogenicity in clinical trials for diseases like rabies, Nipah, Zika, and influenza.
- The rapid design and development capabilities of mRNA platforms are well-suited for emerging infectious diseases.
- mRNA technology holds potential for pre-pandemic preparedness against zoonotic viruses.
Conclusions:
- mRNA vaccines represent a powerful tool for addressing the threat of zoonotic diseases.
- Continued research and development are essential to overcome challenges and optimize mRNA vaccine strategies.
- This platform technology is crucial for future pandemic preparedness and response.
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