Related Experiment Video
Updated: Sep 13, 2025

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
Published on: November 7, 2018
Surface Gene Mutations of Hepatitis B Virus and Related Pathogenic Mechanisms: A Narrative Review
Tingxi Yan1, Yusheng Zhang1, Huifang Zhou1
1Department of Laboratory Medicine, Naval Medical Centre, Naval Medical University, Shanghai 200052, China.
Abstract:
Liver cancer has high incidence and mortality rates worldwide, with hepatocellular carcinoma (HCC) being the main histological subtype, accounting for 90% of primary liver cancers. The high mutation rate of viruses combined with endoplasmic reticulum stress may lead to the occurrence of cancer. Hepatitis B virus (HBV) infection is one of the most important pathogenic factors of HCC. The carcinogenic mechanisms of HBV have been widely studied. Among these mechanisms, immune escape and vaccine escape caused by mutations in the HBV S gene have been reported in numerous studies of patients with chronic hepatitis B. In addition, pre-S1/S2 mutations and surface protein truncation mutations may activate multiple signaling pathways. This activation leads to the abnormal proliferation and differentiation of hepatocytes, thereby contributing to the development of HCC. This review aims to integrate the existing literature, summarize the common mutations in the HBV S gene region, and explore the related pathogenic mechanisms.
Related Concept Videos
Viral Mutations
Mutations in Microorganisms
Mechanisms of Retrovirus-induced Cancers
Leaky Scanning
Viruses with RNA Genomes
Subviral Agents

