Research progress on chitosan-based sutures: a review

Effective wound closure facilitates optimal tissue healing, and sutures are one of the predominant medical textiles utilized for wound closure. Chitosan, a biopolymer derived from chitin, possesses distinctive hemostatic properties, antimicrobial and anti-inflammatory activity, biocompatibility, and biodegradability, making it a prevalent choice for wound closure applications. This review provides a comprehensive summary of the current state of chitosan's application in medical sutures, focusing on recent advancements in the fabrication of chitosan-based sutures through various techniques, including wet spinning, melt spinning, electrospinning, interfacial polyelectrolyte complexes, and coating processes. Furthermore, the challenges and future trends in functionality and preparation technology of chitosan-based sutures were discussed. In conclusion, ongoing advancements in scientific research and technology are anticipated to address current limitations, positioning chitosan-based sutures as an optimal option for surgical applications and enhancing therapeutic outcomes.