Xanthan gum-based formulations for additive manufacturing: Scientific developments in drug delivery and biomedical...

The potential of three-dimensional (3D) printing as an approach for developing advanced, patient-specific, highly accurate, and customizable materials has captured the interest of the pharmaceutical and biomedical sciences sectors. The rheological and biodegradation characteristics of xanthan gum in 3D printed formulations make them an excellent platform technology for drug administration and biological applications, according to research. Applications for 3D printing platforms include transdermal, implantable, ophthalmic, and drug delivery. XG offers a prolonged and controlled release mechanism in the formulations for the administration of drugs. Additionally, it may generate hydrogels, matrix-type systems, and bioadhesive systems, which improve encapsulation efficiency, alter release kinetics, and increase bioavailability. It is a great material to use to make both soft and hard tissues because XG can produce chemically and physically crosslinked hydrogel, which enhances drug delivery and mechanical stability. Research is also being done on XG-based bioinks for 3D printing, which may prove useful for wound healing, bone regeneration, and cartilage repair. In this review, we attempted to evaluate the potential of XG in 3D printing for pharmaceutical and biological applications. The physicochemical and rheological properties of 3D printing are specifically examined, along with the many applications in tissue engineering and drugs delivery.