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Updated: Sep 13, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
Published on: October 2, 2021
Unified image formation theory for microscopy and optical coherence tomography in 4-D space-time
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We develop an image formation theory that encompasses the majority of optical microscopy techniques, which utilize diverse coherent or incoherent light-matter interactions. Using the general principles of quantum physics and applying a four-dimensional representation, we unify the image formation theories of optical systems ranging from classical microscopy to cutting-edge instruments into a single framework in which light is replaced with quantum fields and the interactions are represented using double-sided Feynman diagrams. Our universal methodology requires a four-dimensional aperture that enables sufficient understanding of the associations between the different imaging types and interprets image formation appropriately for all systems, including optical coherence tomography.
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