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Autoimmune rheumatic diseases and manifestations for population screening: a consensus development study.

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  • 1Department of Rheumatology and Immunology, Singapore General Hospital, Singapore.

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Summary

Researchers developed consensus-based lists of autoimmune rheumatic diseases (ARDs) and their manifestations for population screening. This work aims to improve early diagnosis of ARDs through new screening questionnaires.

Keywords:
Early diagnosismass screeningrheumatoid arthritisspondyloarthritissystemic lupus erythematosus

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Area of Science:

  • Rheumatology
  • Public Health
  • Clinical Diagnostics

Background:

  • Self-administered screening questionnaires are crucial for reducing diagnostic delays in autoimmune rheumatic diseases (ARDs).
  • Existing ARD screening tools often lack comprehensive coverage, targeting only specific conditions.
  • A need exists for a broad-spectrum screening tool for common ARDs in the general population.

Purpose of the Study:

  • To establish a list of autoimmune rheumatic diseases (ARDs) suitable for population screening.
  • To identify key manifestations for inclusion in a new ARD screening questionnaire.

Main Methods:

  • Phase 1: Modified Delphi study with rheumatologists to identify target ARDs.
  • Phase 2: Modified nominal group technique involving rheumatologists, other healthcare professionals, and patients to identify manifestations.

Main Results:

  • Ten ARDs were selected for general population screening from an initial 14 candidates.
  • Eighty candidate manifestations were identified, with 59 ultimately selected for the screening questionnaire.

Conclusions:

  • Developed consensus-based lists of ARDs and their manifestations.
  • Provides a foundation for creating new screening questionnaires to aid early ARD diagnosis.