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Vertical transmission of scrub typhus: a case report of congenital infection
Yonghan Luo1,2, Zhenghui Liao3, Xianyao Yang1
1Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People's Republic of China.
Scrub typhus (ST), caused by Orientia tsutsugamushi, is typically transmitted through mite bites, but vertical transmission from mother to infant remains poorly understood. This case presents a 13-day-old female neonate diagnosed with congenital ST. The infant developed severe systemic involvement, including fever, jaundice, respiratory distress, and signs of hemophagocytic lymphohistiocytosis (HLH). Despite broad-spectrum antibiotic therapy, her condition worsened. PCR and serological tests confirmed the diagnosis of ST in both the neonate and the mother, with IgM positivity indicating congenital infection. Following treatment with doxycycline, the patient's condition improved. This case adds to the growing body of evidence supporting the vertical transmission of ST and highlights the need for increased awareness of congenital ST.
Scrub typhus (ST), caused by Orientia tsutsugamushi, is typically transmitted through mite bites, but vertical transmission from mother to infant remains poorly understood. This case presents a 13-day-old female neonate diagnosed with congenital ST. The infant developed severe systemic involvement, including fever, jaundice, respiratory distress, and signs of hemophagocytic lymphohistiocytosis (HLH). Despite broad-spectrum antibiotic therapy, her condition worsened. PCR and serological tests confirmed the diagnosis of ST in both the neonate and the mother, with IgM positivity indicating congenital infection. Following treatment with doxycycline, the patient's condition improved. This case adds to the growing body of evidence supporting the vertical transmission of ST and highlights the need for increased awareness of congenital ST.
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