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Nanomaterial-Based Biosensors for Aflatoxin B1 Detection: Current Advances, Challenges, and Prospects.
Boyan Sun1,2, Qiqi Wang1,2, Sihan Wang3
1State Key Laboratory of Veterinary Public Health and Safety, Key Laboratory for Detection of Veterinary Drug Residues and Illegal Additives of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
Small (Weinheim an Der Bergstrasse, Germany)
|July 30, 2025
Summary
Rapid detection of aflatoxin B1 (AFB1) in food is crucial. Nanomaterial-based biosensors offer a promising solution for sensitive and early AFB1 screening in food and raw materials.
Area of Science:
- Analytical Chemistry
- Food Science
- Materials Science
Background:
- Aflatoxins (AFTs) are potent mycotoxins contaminating food and raw materials.
- Aflatoxin B1 (AFB1) is the most toxic and carcinogenic form, posing risks to animals and humans.
- Efficient, rapid, and sensitive detection methods for AFB1 are urgently needed.
Purpose of the Study:
- To provide a comprehensive review of nanomaterial-based biosensors for AFB1 detection.
- To discuss the potential applications, sensitivity, selectivity, and effectiveness of these biosensors in real samples.
- To highlight novel nanomaterials for AFB1 screening.
Main Methods:
- Review of existing literature on nanomaterial-based biosensors for AFB1 detection.
- Analysis of biosensor performance metrics including sensitivity and selectivity.
- Discussion of various nanomaterials like noble metal nanomaterials, quantum dots, and carbon-based nanomaterials.
Main Results:
- Nanomaterials offer unique properties for enhancing biosensor sensitivity and performance.
- Various nanomaterials show promise for effective AFB1 detection in food matrices.
- Biosensors utilizing noble metal nanomaterials, quantum dots, and carbon-based nanomaterials are highlighted for AFB1 screening.
Conclusions:
- Nanomaterial-based biosensors represent a significant advancement in AFB1 detection technology.
- These biosensors are crucial for ensuring food safety and preventing public health risks.
- This review serves as a foundation for future innovations in AFB1 detection methods.

