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Inverse association between dietary oxidative balance score and myocardial infarction in hypertensive patients: A

Zehao Jin1,2, Xu Li2, Ziyang Huang3

  • 1The Affiliated Yueqing Hospital of Wenzhou Medical University, Yueqing, Zhejiang, China.

Science Progress
|July 30, 2025
PubMed

Insights

A higher dietary oxidative balance score is linked to lower myocardial infarction risk in hypertensive adults. This suggests dietary patterns promoting oxidative balance can help prevent heart attacks in high-risk individuals.

Area of Science:

  • Cardiovascular Health
  • Nutritional Epidemiology
  • Oxidative Stress Research

Background:

  • Hypertension is a significant risk factor for myocardial infarction (MI).
  • The relationship between dietary oxidative balance score (DOBS) and MI risk in hypertensive individuals requires further investigation.

Purpose of the Study:

  • To examine the association between DOBS and MI risk in adults with hypertension.
  • To explore potential nonlinear relationships between DOBS and MI risk.

Main Methods:

  • Cross-sectional analysis of 14,137 hypertensive participants from the National Health and Nutrition Examination Survey (NHANES) (1999-2018).
  • DOBS calculated from 16 dietary components (14 antioxidants, 2 pro-oxidants).
  • Logistic regression and restricted cubic splines used to assess associations.

Main Results:

  • A significant inverse association was found between DOBS and MI risk.
  • Each one-point increase in DOBS correlated with a 2.4% reduction in MI odds (OR: 0.976).
  • Highest DOBS tertile showed a 28.9% lower MI risk compared to the lowest (OR: 0.711).

Conclusions:

  • Elevated DOBS is associated with reduced myocardial infarction risk in hypertensive patients.
  • Dietary patterns focusing on oxidative balance may be a key strategy for MI prevention in this population.

Keywords:
Dietary oxidative balance scorediethypertensionmyocardial infarctionoxidative stress

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