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Prognostic impact of peripheral blood ratio in sinonasal squamous cell carcinoma

  • 0Department of Radiation Oncology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Science Progress +

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July 30, 2025

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July 30, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Peripheral blood ratios like the neutrophil/lymphocyte ratio can predict sinonasal squamous cell carcinoma progression. High lymphocyte/monocyte ratio indicates a poor prognosis, offering valuable insights for patient outcomes.

Area Of Science

  • Oncology
  • Hematology

Background

  • Sinonasal squamous cell carcinoma (SCC) often presents at advanced stages.
  • Predictive indicators for sinonasal SCC prognosis are limited.

Purpose Of The Study

  • To evaluate peripheral blood ratios as prognostic markers for sinonasal SCC.
  • To identify indicators for predicting disease progression in sinonasal SCC patients.

Main Methods

  • Retrospective analysis of 198 sinonasal SCC patients (2010-2022).
  • Calculation of systemic inflammatory response index (SIRI), platelet/lymphocyte ratio (PLR), neutrophil/lymphocyte ratio (NLR), and lymphocyte/monocyte ratio (LMR).
  • Examination of predictive values for overall survival, progression-free survival, and distant metastasis-free survival.

Main Results

  • Significant differences in SIRI, LMR, NLR, and PLR were observed between T4 and T1-3 stages.
  • SIRI, PLR, LMR, and NLR, with specific thresholds, predicted survival outcomes.
  • High LMR was significantly associated with a poor prognosis in multivariate analysis.

Conclusions

  • NLR, SIRI, LMR, and PLR serve as valuable prognostic parameters for sinonasal SCC.
  • LMR is a sensitive predictor of overall survival and distant metastasis-free survival in sinonasal SCC patients.

Keywords: