From Adhesions to Conception: A Case Study on Platelet-Rich Plasma's Role in Gynecologic Recovery

Intrauterine adhesions (IUA) are a common gynecologic disorder usually caused by infection, surgery, or trauma. Its pathogenesis is complex and involves multiple factors such as cytokines, inflammatory responses, and tissue fibrosis. In recent years, diagnostic and therapeutic options for uterine adhesions have evolved, encompassing both traditional surgical methods and emerging biologic therapies. Platelet-rich plasma (PRP) therapy has gradually gained widespread attention in the field of obstetrics and gynecology. Its core concept is to utilize the abundant platelets in the patient's own blood to promote tissue repair and regeneration. The application of PRP by intrauterine instillation or injection can effectively improve endometrial thickness, enhance its receptivity, and subsequently improve pregnancy outcomes. In this paper, we report the case of a 33-year-old female patient who underwent hysterectomy for uterine remnants following a medical abortion. She subsequently developed secondary IUA, presenting as decreased menstrual flow. She initially received hysteroscopic cold knife adhesion separation combined with hormone replacement therapy, which proved ineffective. She later underwent repeat hysteroscopic cold knife adhesiolysis followed by intrauterine perfusion of PRP. After this intervention, her menstrual flow returned to normal, and she successfully conceived and delivered a healthy baby one year later.