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Gut Microbiome Composition Changes During Insomnia Treatment with Lemborexant

Seiko Miyata1, Kunihiro Iwamoto1, Mikako Ito2

  • 1Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.

Nature and Science of Sleep
|July 30, 2025
PubMed
Summary

Lemborexant treatment for insomnia altered gut microbiota, significantly reducing Parabacteroides. This highlights a potential link between hypnotic medications and gut microbial balance in patients with sleep disorders.

Keywords:
elderlygut microbiotahome sleep monitoringinsomnia interventionlemborexantshort-chain fatty acids

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